Nexium, or esomeprazole, relieves a number of tummy-related complaints. It works by blocking a proton pump and reducing the production of acrid in the breadbasket.

They are commonly prescribed to treat bug related to excess stomach acid, including gastrointestinal reflux disease (GERD) and peptic ulcers.

This article will wait at the uses of Nexium, how it works, and any agin effects or precautions.

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Nexium and other PPIs are prescribed for gastro-esophageal reflux disease (GERD) and other gastric weather.

Nexium is a proton pump inhibitor (PPI), one of the most widely sold groups of drugs in the world.

PPIs such equally Nexium reduce stomach acid secretion. They affect the parietal cells in the stomach wall. These cells secrete muriatic acid and intrinsic factor, an important factor in the absorption of vitamin B 12.

The drug works past inhibiting hydrogen potassium ATPase (H+/G+ ATPase), a transporter that is responsible for acidifying the tum.

Nexium is most commonly used to treat the following weather condition:

Dyspepsia, or indigestion: Symptoms include nausea, heartburn, and upper intestinal fullness and pain.

Peptic ulcer disease: At that place is a gap in the lining of the breadbasket, esophagus, or intestine.

Gastroesophageal reflux disease (GERD): A chronic status where breadbasket acid comes upwards from the stomach into the esophagus and amercement the mucosa, leading to heartburn.

Zollinger-Ellison syndrome: A pancreatic tumor overstimulates the product of tummy acid.

Nexium may be used by patients who are taking nonsteroidal anti-inflammatory drugs (NSAIDs). This is due to NSAIDs' propensity to produce tum ulcers; Nexium helps foreclose their germination.

PPIs include Aciphex, Zegerid, Prilosec, Protonix and Prevacid.

The furnishings of Nexium on balmy symptoms are comparable to like drugs. However, Nexium appears to be more effective than some drugs for more severe symptoms.

It also appears to amend esophageal healing rates, compared with some other leading brands.

Nexium comes as a capsule, which prevents information technology from existence released too quickly. A rapid release would cause the medication to exist cleaved down by the stomach acrid.

Other means of taking information technology include mixing granules with water, and delivering this solution through a feeding tube.

It is usually taken once a twenty-four hours, at the same time every twenty-four hours, around 1 hour before eating. For some atmospheric condition, it is taken twice a twenty-four hour period.

Information technology is important to follow the doctor'south instructions and to read the information leaflet carefully.

The nearly common adverse furnishings of Nexium are:

  • headache
  • diarrhea, nausea, and flatulence
  • decreased ambition
  • constipation
  • dry out oral fissure or an unusual taste in the mouth
  • abdominal pain

Less ordinarily, it may lead to:

  • allergic reactions
  • night urine
  • chest or back pain
  • acne
  • changes in heart rhythm
  • fever
  • yellowish coloration of the eyes or skin, known as jaundice
  • extreme fatigue and muscle weakness
  • unusual bleeding or bruising
  • paresthesia, a tingling or prickly awareness
  • persistent sore throat
  • severe stomach pain
  • muscle spasms and shaking
  • diarrhea and watery stools
  • seizures

If anyone has any of these symptoms, they should contact a dr. immediately.

Nexium can requite ascent to some additional problems.

Hip fracture

There is some evidence that long-term apply of esomeprazole tin can increase the chances of hip fracture.

One theory is that PPIs interfere with calcium absorption, which may weaken bones.

Another is that they bear upon normal os recycling past inhibiting proton pumps in the body that are involved in bone creation and remodeling.

I study institute no link between abdominal calcium absorption and PPI use in women after menopause. The researchers notation that this could be because it was a brusk-term investigation, lasting only 30 days, or considering people who use a PPI may have other risk factors already.

Other studies have institute no link between depression calcium absorption and PPI apply.

Clostridium difficile infection

PPIs have been linked with an initial bout of Clostridium difficile infection (CDI) and recurrence. Some researchers suggest that some people are prescribed a PPI without needing 1, and that discontinuing use could reduce the chance of infection.

Pneumonia

One study of data for 63,878 hospital admissions to a hospital in Boston, MA, from January 2004 through Dec 2007, found that patients using PPIs had a 30-percent higher adventure of developing infirmary-acquired pneumonia.

Over half of the patients admitted were prescribed a PPI, and 2,219 of them acquired pneumonia in the hospital, or 3.5 per centum of all the patients.

A study in the U.k. (U.K.) found that outpatients using a PPI had a college risk of pneumonia than the full general population for the first 30 days of using the drug, and especially in the offset ii days.

Polyps

Nexium and other PPIs may be associated with hyperplasia, or a thickening of the stomach lining, which could pb to a benign tumor. Still, evidence supporting this is limited.

Kidney damage

Some studies have found a correlation between PPIs and chronic kidney illness, but it is not clear whether the link is causal.

Nutritional

Some evidence suggests that, considering gastric acid breaks downward nutrient, and considering PPIs reduce the levels of acid, nutritional deficits may occur.

Some researchers have suggested that PPIs might interfere with the assimilation of calcium, fe, and vitamin B 12, simply more studies are needed to confirm this.

There are many confounding variables, nonetheless, and how these factors interact is not yet fully understood. The strongest evidence for nutritional shortfalls is in regard to magnesium.

Nexium is a competitive inhibitor of the enzyme CYP2C19, and so it might affect drugs that rely on this enzyme.

Diazepam and warfarin are broken down by CYP2C19. If these are used alongside a PPI, level of active ingredients in the body might rise.

Clopidogrel (Plavix) needs CYP2C19 to be converted into its active course. Using this blazon of drug alongside Nexium will reduce its upshot.

Changes in stomach acerbity can also bear on the way sure drugs are captivated.

Ketoconazole and atazanavir are best absorbed in an acidic environment. Ketoconazole is an antifungal treatment, and atazanavir is used in HIV therapy,

Erythromycin is degraded by stomach acid. A more than alkaline metal state of affairs will increase absorption.

An overdose can pb to:

  • confusion
  • drowsiness
  • vision problems
  • nausea
  • sweating and flushing
  • headache
  • dry out rima oris
  • rapid heartbeat

In the case of an overdose, contact the local poison control eye or seek medical attention.

Research published in 2016 found that people using a PPI had an 11.8-pct gamble of chronic kidney disease (CKD) over 10 years, compared with an expected take a chance of 8.v pct if they had not used a PPI.

However, it is possible that people who are prescribed a PPI may already be at higher hazard of CKD.

In 2013, over 15 one thousand thousand Americans were using a prescription PPI.

Statistics advise that between 40 and 70 per centum of patients are given some kind of PPI during a stay in the hospital.

Studies suggest that up to 70 percent of PPI use may not be necessary, and that in 25 percent of cases, the person could stop employ it without the risk of developing symptoms.

People who use a PPI and who feel they may not be at take a chance of symptoms should speak to their doctor about the possibility of discontinuing its use.

Always follow the physician's advice when using whatsoever medication, and read the patient information leaflet before utilise.